4,4'-Dimethoxytrityl Chloride (DMT-Cl)
Specifications
- CAS No.
- 40615-36-9
- Molecular formula
- C₂₁H₁₉ClO₂
- Molecular weight
- 338.83
- Appearance
- White to pale yellow Powder
- Melting point
- 123-127℃
- Boiling point
- Not available (decomposes)
Product overview
4,4′-Dimethoxytrityl chloride (DMT-Cl) is a widely used hydroxyl protecting reagent in organic synthesis and nucleic acid chemistry. It is a white to pale yellow crystalline powder that selectively protects the 5′-hydroxyl group of nucleosides, and its characteristic deep-orange DMT cation released upon deprotection allows convenient colorimetric monitoring of oligonucleotide synthesis efficiency. in water. In acidic solutions, it is colorless, while in basic solutions, it turns pink to purple.
Key features
- High purity (≥97%) ensuring reliable protection efficiency
- Selective 5'-hydroxyl protection with mild acidic deprotection conditions
- Stable crystalline solid under dry, inert storage conditions
- Characteristic DMT cation color enables easy UV monitoring of coupling steps
- Standard packaging (25Kg/Drum) available for industrial nucleic acid production
Applications
- Hydroxyl protecting group reagent in oligonucleotide and DNA/RNA synthesis
- 5'-OH protection of nucleosides and nucleotides in phosphoramidite chemistry
- Protecting reagent for pharmaceutical synthesis and nucleic acid medicine production
- Used in automated DNA synthesizers and molecular biology research
- Applied as a trityl-type protecting reagent in fine organic synthesis
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