D-(+)-Methyl-alpha-(2-thienylethylamino)(2-chlorophenyl)acetate hydrochloride
Specifications
- CAS No.
- 141109-19-5
- Appearance
- White to off-white Solid
- Melting point
- 180-182℃
- Boiling point
- Not available (decomposes)
Product overview
D-(+)-Methyl-alpha-(2-thienylethylamino)(2-chlorophenyl)acetate hydrochloride is a key chiral intermediate in the synthesis of clopidogrel, a widely used antiplatelet drug. It is a white to off-white solid with high optical purity, formed by condensation of (S)-(+)-2-chlorophenylglycine methyl ester with 2-(2-thienyl)ethylamine and converted to the hydrochloride salt for stability and handling. in water. In acidic solutions, it is colorless, while in basic solutions, it turns pink to purple.
Key features
- High optical purity (D-(+)-configuration) meeting clopidogrel process requirements
- Stable hydrochloride salt form with well-defined melting point (180-182℃)
- White to off-white solid, easy to weigh, store and transport
- Low impurity profile suitable for downstream API synthesis
- Standard packaging (25Kg/Drum) suitable for industrial scale production
Applications
- Key intermediate in the industrial synthesis of clopidogrel bisulfate API
- Chiral building block for thienyl-containing pharmaceutical compounds
- Used in pharmaceutical process development and scale-up production
- Raw material for antiplatelet drug manufacturing in the pharmaceutical industry
- Applied in fine chemical synthesis of 2-thienylethylamine derivatives
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